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KMID : 0366219900250020507
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Korean Journal of Hematology
1990 Volume.25 No. 2 p.507 ~ p.513
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Interferon - Alpha2a Plus Hydroxyurea therapy in CML
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김삼용/Samyong Kim
장준/성기양/길준영/윤일국/이경숙/김종완/서종진/Joon Jang/Ki Yang Sung/Jun Young Kil/Il Kuk Yoon/Kyung Sook Lee/Jong Wan Kim/Jong Jin Seo
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Abstract
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To evaluate the therapeutic effect and toxicity, 11 patients with chronic myelogenous
leukemia were treated with Interferon-alpha2a (3-6×106Units/day, i.m. 3
times per week) and hydroxyurea (1-3gm/day, p.o×7days, every three week).
10 patients (91%) achieved hematologic responses (4 complete hematologic response, 6
partial hematologic response). The median duration of response was 2 months (2-7
months). 4 of 11 patients (36%) obtained cytogenetic improvement on follow-up
chromosome analysis of bone marrow cells; 2 partial responses (Ph1≤
35%)and 2 minor response (Ph1≤ 50%). Early toxicities of
Interferon-alpha2a therapy (fatigue, malaise, fever, chill) were noted in 64-100% of
patients, but were well controlled with acetaminophen. 3 patients died of blastic
transformation during therapy.
The long term results of this trial need to be followed by more patient accrual 1) to
evaluate whether this combined therapy could change the natural history of CML 2) to
define its therapeutic role in CML.
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KEYWORD
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